NF-κB
NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.
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Prostratin是PKC的激动剂， 也是NF-κB的激动剂。
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JSH-23抑制NF-κB的转录活性，IC50为7.1 μM。
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Caffeic acid phenethyl ester是一种强效的特异性NF-κB活化抑制剂，也能够表现出抗氧化、免疫调节和抗炎活性。
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QNZ
EY0813
QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生，IC50分别为11 nM和7 nM。
More
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Prostratin是PKC的激动剂， 也是NF-κB的激动剂。
More
-
JSH-23抑制NF-κB的转录活性，IC50为7.1 μM。
More
-
More
-
Caffeic acid phenethyl ester是一种强效的特异性NF-κB活化抑制剂，也能够表现出抗氧化、免疫调节和抗炎活性。
More
-
QNZ
EY0813
QNZ (EVP4593)有效抑制NF-κB激活和TNF-α产生，IC50分别为11 nM和7 nM。
More
